Pub. Date : 2013 May
PMID : 23378049
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TAK1 activates AMPK-dependent cell death pathway in hydrogen peroxide-treated cardiomyocytes, inhibited by heat shock protein-70. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 2 | The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 3 | The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 4 | The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 5 | The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 6 | The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 7 | The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 8 | The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 9 | The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 10 | We observed a significant AMPK activation in H2O2-treated cardiomyocytes (both primary cells and H9c2 line). | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 11 | Inhibition of AMPK by its inhibitor or RNAi-reduced H2O2-induced cardiomyocyte death. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 12 | We here proposed that transforming growth factor-beta-activating kinase 1 (TAK1) might be the upstream kinase for AMPK activation by H2O2. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 13 | H2O2-induced TAK1 activation, which recruited and activated AMPK. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 14 | TAK1 inhibitor significantly suppressed H2O2-induced AMPK activation and following cardiomyocyte death, while over-expression of TAK1-facilitated AMPK activation and aggregated cardiomyocyte death. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 15 | In conclusion, we here suggest that TAK1 activates AMPK-dependent cell death pathway in H2O2-treated cardiomyocytes, and HSP-70 inhibits the signaling pathway by reducing ROS content. | Hydrogen Peroxide | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |