Title : Risedronate increases osteoblastic differentiation and function through connexin43.

Pub. Date : 2013 Mar 1

PMID : 23376077






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Risedronate dose-dependently increased the activity of osterix (OSE)-luciferase containing Runx2 response element with highest activity at 50muM. Risedronic Acid RUNX family transcription factor 2 Homo sapiens
2 In the presence of Runx2 or Dlx5, risedronate had an additive effect on Cx43 promoter activity. Risedronic Acid RUNX family transcription factor 2 Homo sapiens
3 Accordingly, risedronate increased protein expression of Cx43, Runx2, Osterix, and Dlx5. Risedronic Acid RUNX family transcription factor 2 Homo sapiens