Title : Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses.

Pub. Date : 2013

PMID : 23372648






1 Functional Relationships(s)
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1 Since synaptic alteration is the best pathologic correlate of cognitive dysfunction in AD, the spatial association of M/LMW Abeta peptide accumulation with pathology of MAP2 within neuronal processes and synaptic compartments early in the disease process reinforces the importance of intraneuronal Abeta accumulation in AD pathogenesis. UNII-042A8N37WH microtubule-associated protein 2 Mus musculus