Pub. Date : 2013 Apr
PMID : 23371966
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics. | Anastrozole | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 2 | In this study, we examined individual variability in the glucuronidation of anastrozole and its association with UGT1A4 promoter and coding region polymorphisms. | Anastrozole | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 3 | Anastrozole glucuronidation was correlated (r = 0.99; P < 0.0001) with lamotrigine glucuronidation (a diagnostic substrate for UGT1A4) and with UGT1A4 mRNA expression levels in human liver microsomes (r = 0.99; P < 0.0001). | Anastrozole | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 4 | Anastrozole glucuronidation was correlated (r = 0.99; P < 0.0001) with lamotrigine glucuronidation (a diagnostic substrate for UGT1A4) and with UGT1A4 mRNA expression levels in human liver microsomes (r = 0.99; P < 0.0001). | Anastrozole | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 5 | Recombinant UGT1A4 catalyzed anastrozole glucuronidation, which was inhibited by hecogenin (IC50 = 15 microM), a UGT1A4 specific inhibitor. | Anastrozole | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 6 | Recombinant UGT1A4 catalyzed anastrozole glucuronidation, which was inhibited by hecogenin (IC50 = 15 microM), a UGT1A4 specific inhibitor. | Anastrozole | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |