Title : Anticancer activity of fish oils against human lung cancer is associated with changes in formation of PGE2 and PGE3 and alteration of Akt phosphorylation.

Pub. Date : 2014 Jul

PMID : 23371504






4 Functional Relationships(s)
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1 Here we investigated the effect of eicosapentaenoic acid (EPA) on the proliferation of human non-small cell lung cancer A549 (COX-2 over-expressing) and H1299 (COX-2 null) cells as well as their xenograft models. Eicosapentaenoic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Intriguingly, when COX-2 expression was reduced by siRNA or shRNA in A549 cells, the antiproliferative activity of EPA was reduced substantially compared to that of control siRNA or shRNA transfected A549 cells. Eicosapentaenoic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 Taken together, the results of our study suggest that the ability of EPA to generate PGE3 through the COX-2 enzyme might be critical for EPA-mediated tumor growth inhibition which is at least partly due to down-regulation of Akt phosphorylation by PGE3. Eicosapentaenoic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens
4 Taken together, the results of our study suggest that the ability of EPA to generate PGE3 through the COX-2 enzyme might be critical for EPA-mediated tumor growth inhibition which is at least partly due to down-regulation of Akt phosphorylation by PGE3. Eicosapentaenoic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens