Title : Modeling of lamin A/C mutation premature cardiac aging using patient‐specific induced pluripotent stem cells.

Pub. Date : 2012 Nov

PMID : 23362510






2 Functional Relationships(s)
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1 Pharmacological blockade of ERK1/2 pathway with MEK1/2 inhibitors, U0126 and selumetinib (AZD6244) significantly attenuated the pro-apoptotic effects of field electric stimulation on the mutated LMNA iPSC-CMs. AZD 6244 mitogen-activated protein kinase 3 Homo sapiens
2 Pharmacological blockade of ERK1/2 pathway with MEK1/2 inhibitors, U0126 and selumetinib (AZD6244) significantly attenuated the pro-apoptotic effects of field electric stimulation on the mutated LMNA iPSC-CMs. AZD 6244 mitogen-activated protein kinase 3 Homo sapiens