Title : Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites.

Pub. Date : 2013 Mar 15

PMID : 23362255






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Tau phosphorylation occurs mainly at proline-directed Ser/Thr sites, which are targeted by protein kinases such as GSK3beta and Cdk5. Proline microtubule associated protein tau Homo sapiens
2 We reported previously that dephosphorylation of Tau at Cdk5-mediated sites was enhanced by Pin1, a peptidyl-prolyl isomerase that stimulates dephosphorylation at proline-directed sites by protein phosphatase 2A. Proline microtubule associated protein tau Homo sapiens