Title : Interferon-γ promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2.

Pub. Date : 2013 Aug

PMID : 23359533






1 Functional Relationships(s)
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1 Bosentan treatment was more effective than TGFbeta blockade in reversing the actions of IFN-gamma, including downregulation of alpha-SMA and TGFbeta2, suggesting that activation of the ET-1 pathway plays a main role in the IFN-gamma responses in HDMECs. Bosentan endothelin 1 Homo sapiens