Title : Thrombin-induced NF-κB activation and IL-8/CXCL8 release is mediated by c-Src-dependent Shc, Raf-1, and ERK pathways in lung epithelial cells.

Pub. Date : 2013 May

PMID : 23357535






1 Functional Relationships(s)
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1 Thrombin-induced increases in IL-8/CXCL8 release and kappaB-luciferase activity were inhibited by the Shc small interfering RNA (siRNA), p66Shc siRNA, GW 5074 (a Raf-1 inhibitor), and PD98059 (a mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitor). 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone coagulation factor II, thrombin Homo sapiens