Title : Cyclic AMP enhances TGFβ responses of breast cancer cells by upregulating TGFβ receptor I expression.

Pub. Date : 2013

PMID : 23349840






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 We found that cAMP potentiated TGFbeta-dependent gene expression by enhancing Smad3 phosphorylation. Cyclic AMP SMAD family member 3 Homo sapiens
2 Two Smad3 regulating proteins, YAP (Yes-associated protein) and TbetaRI (TGFbeta receptor 1), were responsive to cAMP. Cyclic AMP SMAD family member 3 Homo sapiens