Title : H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse.

Pub. Date : 2013 Jul

PMID : 23347954






2 Functional Relationships(s)
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1 Rho-kinase (ROCK) inhibitor Y27632 reduced brain level of polyglutamine-expanded huntingtin in HD transgenic mouse. polyglutamine Rho associated coiled-coil containing protein kinase 1 Homo sapiens
2 Therefore, we tested the possibility that ROCK inhibitors, Y27632, H1152 and GSK429286, downregulate protein expression of polyglutamine-expanded ataxin-3-Q79. polyglutamine Rho associated coiled-coil containing protein kinase 1 Homo sapiens