Title : Antisense 2'-Deoxy, 2'-Fluroarabino Nucleic Acids (2'F-ANAs) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids.

Pub. Date : 2012 Sep 18

PMID : 23344235






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In LNCaP prostate cancer cells, gymnotic silencing of the AR by a 2"F-ANA phosphorothioate gapmer oligo led to downstream silencing of cellular prostate-specific antigen (PSA) expression even in the presence of the androgenic steroid R1881 (metribolone), which stabilizes cytoplasmic levels of the AR. Steroids kallikrein related peptidase 3 Homo sapiens