Title : Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo.

Pub. Date : 2013

PMID : 23342112






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. trichostatin A tumor protein p53 Homo sapiens
2 We first showed that quercetin (5 microM) significantly increased the growth arrest and apoptosis in A549 cells (expressing wild-type p53) induced by 25 ng/mL of (82.5 nM) TSA at 48 h by about 25% and 101%, respectively. trichostatin A tumor protein p53 Homo sapiens
3 In addition, quercetin significantly increased TSA-induced p53 expression in A549 cells. trichostatin A tumor protein p53 Homo sapiens
4 These data indicate that regulation of the expression of p53 by quercetin plays an important role in enhancing TSA-induced apoptosis in A549 cells. trichostatin A tumor protein p53 Homo sapiens