Pub. Date : 2013
PMID : 23342112
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. | trichostatin A | tumor protein p53 | Homo sapiens |
| 2 | We first showed that quercetin (5 microM) significantly increased the growth arrest and apoptosis in A549 cells (expressing wild-type p53) induced by 25 ng/mL of (82.5 nM) TSA at 48 h by about 25% and 101%, respectively. | trichostatin A | tumor protein p53 | Homo sapiens |
| 3 | In addition, quercetin significantly increased TSA-induced p53 expression in A549 cells. | trichostatin A | tumor protein p53 | Homo sapiens |
| 4 | These data indicate that regulation of the expression of p53 by quercetin plays an important role in enhancing TSA-induced apoptosis in A549 cells. | trichostatin A | tumor protein p53 | Homo sapiens |