Title : Development of a recombinant cell-based indirect immunofluorescence assay (RC-IFA) for the determination of autoantibodies against "rings and rods"-associated inosine-5'-monophosphate dehydrogenase 2 in viral hepatitis C.

Pub. Date : 2013 Mar 15

PMID : 23333419






3 Functional Relationships(s)
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1 Development of a recombinant cell-based indirect immunofluorescence assay (RC-IFA) for the determination of autoantibodies against "rings and rods"-associated inosine-5"-monophosphate dehydrogenase 2 in viral hepatitis C. BACKGROUND AND AIMS: Autoantibodies against so-called "rings and rods" structures, as determined by indirect immunofluorescence assay (IFA) using the human cell line HEp-2, have been described in chronic hepatitis C virus (HCV) infected patients treated with interferon/ribavirin. Ribavirin inosine monophosphate dehydrogenase 2 Homo sapiens
2 Recently, cytidine triphosphate synthase (CTPS) and inosine-5"-monophosphate dehydrogenase 2 (IMPDH2), the enzyme inhibited by ribavirin, were proposed as the target antigens. Ribavirin inosine monophosphate dehydrogenase 2 Homo sapiens
3 Recently, cytidine triphosphate synthase (CTPS) and inosine-5"-monophosphate dehydrogenase 2 (IMPDH2), the enzyme inhibited by ribavirin, were proposed as the target antigens. Ribavirin inosine monophosphate dehydrogenase 2 Homo sapiens