Title : Melatonin potentiates the antiproliferative and pro-apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways.

Pub. Date : 2013 May

PMID : 23330808






3 Functional Relationships(s)
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1 Moreover, we found that the enhanced effects of UA and melatonin combination are mediated through simultaneous modulation of cytochrome c/caspase, MMP9/COX-2, and p300/NF-kappaB signaling pathways. Melatonin mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells. Melatonin mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells. Melatonin mitochondrially encoded cytochrome c oxidase II Homo sapiens