Title : [Effect of tacrolimus on the pharmacokinetics and glucuronidation of SN-38, an active metabolite of irinotecan].

Pub. Date : 2013

PMID : 23328499






2 Functional Relationships(s)
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1 SN-38 glucuronidation in human and rat liver microsomes was inhibited dose-dependently by the presence of tacrolimus and the 50% inhibition concentration (IC50) values of tacrolimus in rat and human liver microsomes were 10.33 muM and 3.58 muM, respectively. Tacrolimus latexin Homo sapiens
2 SN-38 glucuronidation in human and rat liver microsomes was inhibited dose-dependently by the presence of tacrolimus and the 50% inhibition concentration (IC50) values of tacrolimus in rat and human liver microsomes were 10.33 muM and 3.58 muM, respectively. Tacrolimus latexin Homo sapiens