Pub. Date : 2013 Jan 15
PMID : 23320839
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of gemcitabine or doxorubicin activated phosphorylated ERK and induced the upregulation of MRP1 and MRP3. | Doxorubicin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | MEK inhibitors U0126 and AZD6244 deactivated phosphorylated ERK, decreased endogenous MRP1 expression, reversed gemcitabine or doxorubicin induced MRP1 and MRP3 upregulation, and increased the intracellular doxorubicin accumulation. | Doxorubicin | mitogen-activated protein kinase 1 | Homo sapiens |