Title : MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma.

Pub. Date : 2013 Jan 15

PMID : 23320839






2 Functional Relationships(s)
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1 Treatment of gemcitabine or doxorubicin activated phosphorylated ERK and induced the upregulation of MRP1 and MRP3. Doxorubicin ATP binding cassette subfamily C member 1 Homo sapiens
2 MEK inhibitors U0126 and AZD6244 deactivated phosphorylated ERK, decreased endogenous MRP1 expression, reversed gemcitabine or doxorubicin induced MRP1 and MRP3 upregulation, and increased the intracellular doxorubicin accumulation. Doxorubicin ATP binding cassette subfamily C member 1 Homo sapiens