Title : Self double-stranded (ds)DNA induces IL-1β production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies.

Pub. Date : 2013 Feb 15

PMID : 23315075






1 Functional Relationships(s)
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1 These findings provide new insights in lupus pathogenesis by demonstrating that self dsDNA together with its autoantibodies induces IL-1beta production from human monocytes by activating the NLRP3 inflammasome through inducing ROS synthesis and K(+) efflux, leading to the increased Th17 cell response. Reactive Oxygen Species NLR family pyrin domain containing 3 Homo sapiens