Pub. Date : 2013 Feb 15
PMID : 23315075
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | These findings provide new insights in lupus pathogenesis by demonstrating that self dsDNA together with its autoantibodies induces IL-1beta production from human monocytes by activating the NLRP3 inflammasome through inducing ROS synthesis and K(+) efflux, leading to the increased Th17 cell response. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |