Pub. Date : 2013 Jun
PMID : 23307660
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retrograde cPLA2alpha/arachidonic acid/2-AG signaling is essential for cerebellar depolarization-induced suppression of excitation and long-term potentiation. | Arachidonic Acid | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |
| 2 | Cytosolic phospholipase A2 alpha (cPLA2alpha) responds to micromolar intracellular Ca(2+) and produces arachidonic acid, which regulates cellular homeostasis, neurotoxicity, and inflammation. | Arachidonic Acid | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |
| 3 | Our data showed that DSE was significantly inhibited but rescued by arachidonic acid in cPLA2alpha knockout mice. | Arachidonic Acid | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |
| 4 | Co-application of paxilline reversed the blockade of DSE by internal K(+), indicating that large-conductance Ca(2+)-activated potassium channel is sufficient to inhibit cPLA2alpha/arachidonic acid-mediated DSE. | Arachidonic Acid | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |
| 5 | Therefore, these data showed that cPLA2alpha/arachidonic acid/2-AG signaling pathway mediates DSE and LTP at parallel fiber-Purkinje cell synapse. | Arachidonic Acid | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |