Title : Activation of ERM-family proteins via RhoA-ROCK signaling increases intestinal P-gp expression and leads to attenuation of oral morphine analgesia.

Pub. Date : 2013 Mar

PMID : 23303573






2 Functional Relationships(s)
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1 Previously, we reported that repeated oral treatment with etoposide (ETP) causes attenuation of oral morphine analgesia through upregulation of ileal P-glycoprotein (P-gp) mediated by Ras homolog gene family, member A (RhoA) activation. Morphine ATP binding cassette subfamily B member 1 Homo sapiens
2 Previously, we reported that repeated oral treatment with etoposide (ETP) causes attenuation of oral morphine analgesia through upregulation of ileal P-glycoprotein (P-gp) mediated by Ras homolog gene family, member A (RhoA) activation. Morphine ATP binding cassette subfamily B member 1 Homo sapiens