Title : Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.

Pub. Date : 2013 Feb 22

PMID : 23303191






2 Functional Relationships(s)
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1 Mammals have three homologous genes encoding proteins with hyaluronan synthase activity (Has1-3), all producing an identical polymer from UDP-N-acetylglucosamine and UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid hyaluronan synthase 1 Homo sapiens
2 Comparison of different human cell types revealed ~50-fold differences in the content of UDP-N-acetylhexosamines and UDP-glucuronic acid, correlating with the expression level of Has1, suggesting cellular coordination between Has1 expression and the content of UDP-sugars. Uridine Diphosphate Glucuronic Acid hyaluronan synthase 1 Homo sapiens