Pub. Date : 2014 Feb
PMID : 23301526
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tacrolimus abrogates TGF-beta1-induced type I collagen production in normal human fibroblasts through suppressing p38MAPK signalling pathway: implications on treatment of chronic atopic dermatitis lesions. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |
| 2 | Tacrolimus (FK506) ointment has been reported to be effective for treating AD as well as some TGF-beta1-induced fibrotic diseases. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |
| 3 | Tacrolimus (FK506) ointment has been reported to be effective for treating AD as well as some TGF-beta1-induced fibrotic diseases. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |
| 4 | OBJECTIVES: To evaluate the effect of tacrolimus on TGF-beta1-stimulated cultured normal human dermal fibroblasts and explore the potential signalling pathways involved. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |
| 5 | RESULTS: Our results revealed that the increased expressions of transforming growth factor-beta receptor I (TGF-betaRI) and TGF-betaRII in TGF-beta1-treated fibroblasts were suppressed by tacrolimus treatment. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |
| 6 | In addition, tacrolimus significantly inhibited fibroblast proliferation enhanced by TGF-beta1. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |
| 7 | TGF-beta1 increased type I collagen production, and this enhancing effect was suppressed by tacrolimus. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |
| 8 | The down-regulation of MMP-1 and up-regulation of TIMP-1 induced by TGF-beta1 were reversed by tacrolimus. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |
| 9 | The increase in phosphorylated p38 mitogen-activated protein kinase (p38MAPK) expression stimulated by TGF-beta1 was down-regulated by tacrolimus. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |
| 10 | CONCLUSIONS: The present results demonstrated that tacrolimus significantly inhibited physiological functions of fibroblasts enhanced by TGF-beta1 in vitro. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |