Title : NF1 deficiency causes Bcl-xL upregulation in Schwann cells derived from neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.

Pub. Date : 2013 Feb

PMID : 23292448






2 Functional Relationships(s)
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1 We also discovered that the increased Bcl-xL expression caused an increase in drug resistance to doxorubicin in MPNST-derived SCs. Doxorubicin BCL2 like 1 Homo sapiens
2 As the reduction of Bcl-xL expression restored sensitivity to doxorubicin-induced apoptosis in sNF96.2 cells, we examined the effect of the small molecule Bcl-xL inhibitor ABT-737 on sNF96.2 cells. Doxorubicin BCL2 like 1 Homo sapiens