Pub. Date : 2013 Jan 5
PMID : 23289871
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of COX-2 expression by topical diclofenac enhanced radiation sensitivity via enhancement of TRAIL in human prostate adenocarcinoma xenograft model. | Diclofenac | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | In this study, we tested if topical diclofenac, which inhibits both COX-1 and COX-2, administration rendered prostate tumor cells sensitize to the effects of radiation. | Diclofenac | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | In addition, we assessed the tumor volumes of xenograft LNCaP-COX-2 cells treated with topical diclofenac with or without radiation therapy (RT). | Diclofenac | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | RESULTS: LNCaP-COX-2 and LNCaP-Neo cell lines experienced cytotoxic effects of diclofenac in a dose related manner. | Diclofenac | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 5 | Furthermore, the addition of diclofenac sensitized LNCaP-COX-2 not but LNCaP-Neo cells to the cytocidal effects of radiation. | Diclofenac | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 6 | In LNCaP-COX-2 cells, diclofenac enhanced radiation-induced apoptosis compared with RT alone. | Diclofenac | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 7 | CONCLUSIONS: These in vitro and in vivo findings suggest that conventional COX inhibitor, diclofenac enhances the effect of RT on prostate cancer cells that express COX-2. | Diclofenac | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |