Title : Mouse prion protein polymorphism Phe-108/Val-189 affects the kinetics of fibril formation and the response to seeding: evidence for a two-step nucleation polymerization mechanism.

Pub. Date : 2013 Feb 15

PMID : 23283973






1 Functional Relationships(s)
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Protein Name
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1 In mice, the presence of allele a (Prnp(a), encoding the polymorphism Leu-108/Thr-189) or b (Prnp(b), Phe-108/Val-189) is associated with short or long incubation times, respectively, following infection with PrP(Sc). Threonine prion protein Mus musculus