Title : Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.

Pub. Date : 2013 Feb 14

PMID : 23281824






1 Functional Relationships(s)
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Protein Name
Organism
1 Two analogues of 17f, namely 18b and 19a, inhibit MAO-B with IC(50) of 68 and 48 nM, respectively, being 5-7-fold more potent than the prototypical MAO-B inhibitor deprenyl (IC(50) = 334 nM). Selegiline monoamine oxidase B Homo sapiens