Pub. Date : 2013 Mar
PMID : 23279934
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin induces neuroprotection in 6-OHDA-lesioned PC12 via the PI3K/AKT/caspase 3 pathway and anti-inflammatory responses. | Simvastatin | caspase 3 | Rattus norvegicus |
| 2 | This study aims to investigate how simvastatin affects 6-hydroxydopamine-lesioned PC12 via regulating PI3K/AKT/caspase 3 and modulating inflammatory mediators. | Simvastatin | caspase 3 | Rattus norvegicus |
| 3 | Simvastatin reversed 6-OHDA-induced downregulation of PI3K/Akt phosphorylation and attenuated 6-OHDA-induced upregulation of caspase 3 in PC12. | Simvastatin | caspase 3 | Rattus norvegicus |
| 4 | Furthermore, the PI3K inhibitor LY294002 pronouncedly abolished the simvastatin-mediated attenuation in caspase 3. | Simvastatin | caspase 3 | Rattus norvegicus |
| 5 | CONCLUSIONS: Our results demonstrate that simvastatin provides robust neuroprotection against dopaminergic neurodegeneration, partially via antiinflammatory mechanisms and the PI3K/Akt/caspase 3 pathway. | Simvastatin | caspase 3 | Rattus norvegicus |