Title : Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells.

Pub. Date : 2013 Feb 22

PMID : 23275337






1 Functional Relationships(s)
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1 Here, we demonstrate that incubation (2 h) of murine islets or Min6 beta cell line with the SSRIs paroxetine, fluoxetine, or sertraline inhibited insulin-induced Tyr phosphorylation of insulin receptor substrate (IRS)-2 protein and the activation of its downstream targets Akt and the ribosomal protein S6 kinase-1 (S6K1). Paroxetine thymoma viral proto-oncogene 1 Mus musculus