Title : Cationic nanoparticles disrupt cellular signaling in a cholesterol dependent manner.

Pub. Date : 2013 Jun

PMID : 23274767






2 Functional Relationships(s)
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1 However, the activity of the cationic nanoparticles on the IL-8 promoter and NF-kappaB translocation is lost when cholesterol is depleted from A549 cells before particle exposure, which suggests that cationic nanoparticles rely on membrane cholesterol integrity to disrupt cellular signaling. Cholesterol C-X-C motif chemokine ligand 8 Homo sapiens
2 However, the activity of the cationic nanoparticles on the IL-8 promoter and NF-kappaB translocation is lost when cholesterol is depleted from A549 cells before particle exposure, which suggests that cationic nanoparticles rely on membrane cholesterol integrity to disrupt cellular signaling. Cholesterol C-X-C motif chemokine ligand 8 Homo sapiens