Title : [Inhibitory effect of cyclopamine on metastatic ability of EC109 cells and its mechanism].

Pub. Date : 2012 Dec

PMID : 23268421






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Cyclopamine treatment significantly lowered the expression of Gli-1 mRNA (P<0.05) and the protein expressions of Gli-1, MMP-9 and VEGF (P<0.05). cyclopamine matrix metallopeptidase 9 Homo sapiens
2 CONCLUSION: Cyclopamine can significantly inhibit the metastatic capacity of EC109 cells possibly by down-regulating MMP-9 and VEGF expression as a result of Gli-1 inhibition. cyclopamine matrix metallopeptidase 9 Homo sapiens