Title : Bruton's Tyrosine Kinase mediates platelet receptor-induced generation of microparticles: a potential mechanism for amplification of inflammatory responses in rheumatoid arthritis synovial joints.

Pub. Date : 2013 Feb

PMID : 23266841






3 Functional Relationships(s)
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Protein Name
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1 The signaling process by which engagement of glycoprotein VI (GPVI), a surface glycoprotein receptor for collagen which is expressed on platelets, triggers pMP generation is poorly understood, but has been suggested to involve Spleen Tyrosine Kinase (SYK), best known as an upstream activator of Bruton"s Tyrosine Kinase (BTK) in B cells. pmp glycoprotein VI platelet Homo sapiens
2 The signaling process by which engagement of glycoprotein VI (GPVI), a surface glycoprotein receptor for collagen which is expressed on platelets, triggers pMP generation is poorly understood, but has been suggested to involve Spleen Tyrosine Kinase (SYK), best known as an upstream activator of Bruton"s Tyrosine Kinase (BTK) in B cells. pmp glycoprotein VI platelet Homo sapiens
3 A potent and selective BTK inhibitor, RN486, inhibited GPVI- or CLEC2-mediated PLCgamma2 phosphorylation and pMP production in a dose-dependent manner. pmp glycoprotein VI platelet Homo sapiens