Title : Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.

Pub. Date : 2013 Feb 8

PMID : 23258538






2 Functional Relationships(s)
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1 These studies show for the first time that dopaminergic neurons expressing mitochondrial CYP2D6 are fully capable of activating the pro-neurotoxin MPTP and inducing neuronal damage, which is effectively prevented by the CYP2D6 inhibitor quinidine. Quinidine cytochrome P450 family 2 subfamily D member 6 Homo sapiens
2 These studies show for the first time that dopaminergic neurons expressing mitochondrial CYP2D6 are fully capable of activating the pro-neurotoxin MPTP and inducing neuronal damage, which is effectively prevented by the CYP2D6 inhibitor quinidine. Quinidine cytochrome P450 family 2 subfamily D member 6 Homo sapiens