Title : Chronic oxidative stress upregulates Drusen-related protein expression in adult human RPE stem cell-derived RPE cells: a novel culture model for dry AMD.

Pub. Date : 2013 Jan

PMID : 23257616






2 Functional Relationships(s)
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1 RESULTS: hRPE cells exposed to a regimen of TBHP for 5 days upregulate expression of several molecules identified in drusen, including molecular chaperones and pro-angiogenic factors. tert-Butylhydroperoxide ribulose-5-phosphate-3-epimerase Homo sapiens
2 This adult stem cell-based system using chronic TBHP treatment of hRPE represents a novel in vitro model useful for the study of drusen formation and dry AMD pathophysiology. tert-Butylhydroperoxide ribulose-5-phosphate-3-epimerase Homo sapiens