Title : Identification of multiple binding sites for substrate transport in bovine organic anion transporting polypeptide 1a2.

Pub. Date : 2013 Mar

PMID : 23255551






1 Functional Relationships(s)
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1 Further study on other Oatp1a2 substrates showed that the high affinity component for E-3-S is responsible for the interaction with taurocholate, bromsulphthalein, and rifampicin and is sensitive to proton concentration change, whereas the low affinity binding site is only involved in the binding of the antitumor drug methotrexate and had no response to change of pH. Taurocholic Acid solute carrier organic anion transporter family member 1A2 Homo sapiens