Title : Salvianolic Acid B Attenuates Rat Hepatic Fibrosis via Downregulating Angiotensin II Signaling.

Pub. Date : 2012

PMID : 23243430






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The results showed that Sal B and perindopril inhibited rat hepatic fibrosis and reduced expression of Ang II receptor type 1 (AT1R) and ERK activation in fibrotic liver. salvianolic acid B Eph receptor B1 Rattus norvegicus
2 Sal B and losartan also inhibited Ang II-stimulated HSC activation including cell proliferation and expression of type I collagen I (Col-I) and alpha-smooth muscle actin (alpha-SMA) production in vitro, reduced the gene expression of transforming growth factor beta (TGF-beta), and downregulated AT1R expression and ERK and c-Jun phosphorylation. salvianolic acid B Eph receptor B1 Rattus norvegicus