Title : Inhibition of matrix metalloproteinases and inducible nitric oxide synthase by andrographolide in human osteoarthritic chondrocytes.

Pub. Date : 2013 Nov

PMID : 23242626






2 Functional Relationships(s)
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1 OBJECTIVE: The aim of this study was to investigate the effects of andrographolide on matrix metalloproteinases (MMP) 1, 3, and 13 and inducible nitric oxide synthase (iNOS) in human articular chondrocytes from osteoarthritic cartilage. andrographolide matrix metallopeptidase 1 Homo sapiens
2 RESULTS: Andrographolide tested in these in vitro studies was found be an effective antiarthritic agent, as evidenced by potent inhibition of MMP-1, 3, and 13 and iNOS expression, as well as upregulation of TIMP-1 in IL-1beta-stimulated human articular chondrocytes (p < 0.05). andrographolide matrix metallopeptidase 1 Homo sapiens