Title : Human pharmacogenetic analysis in chimeric mice with 'humanized livers'.

Pub. Date : 2013 Feb

PMID : 23241944






1 Functional Relationships(s)
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1 RESULTS: The rate of generation of human-predominant drug metabolites for S-mephenytoin and diclofenac in the chimeric mice was correlated with the CYP2C19 (n=9 donors, P=0.0005) or CYP2C9 (n=7 donors, P=0.0394) genotype, respectively, of the transplanted human hepatocytes. Mephenytoin cytochrome P450 family 2 subfamily C member 19 Homo sapiens