Pub. Date : 2012 Dec 14
PMID : 23241075
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | When women defined by ER status were analyzed separately, regression analysis in the ER-positive group showed a significant association of high testosterone levels with AR-highly-positive expression (OR 1.86; 95% CI, 1.10-3.16), but the association was essentially due to patients greater than or equal to 65 years (OR 2.42; 95% CI, 1.22-4.82). | Testosterone | estrogen receptor 1 | Homo sapiens |
| 2 | When women defined by ER status were analyzed separately, regression analysis in the ER-positive group showed a significant association of high testosterone levels with AR-highly-positive expression (OR 1.86; 95% CI, 1.10-3.16), but the association was essentially due to patients greater than or equal to 65 years (OR 2.42; 95% CI, 1.22-4.82). | Testosterone | estrogen receptor 1 | Homo sapiens |
| 3 | In ER-positive group, elevated testosterone levels appeared also associated with AR-absent expression, although the small number of patients in this category limited the appearance of significant effects (OR 1.92; 95% CI, 0.73-5.02): the association was present in both age groups (<65 and >=65 years). | Testosterone | estrogen receptor 1 | Homo sapiens |
| 4 | In the ER-negative group, elevated testosterone levels were found associated (borderline significance) with AR-absent expression (OR 2.82, 95% CI, 0.98-8.06). | Testosterone | estrogen receptor 1 | Homo sapiens |
| 5 | In this ER-negative/AR-absent subset of tumors, elevated testosterone levels cannot stimulate cancer growth either directly or after conversion into estrogens, but they probably induce increased synthesis of some other substance that is responsible for cancer growth through binding to its specific receptor. | Testosterone | estrogen receptor 1 | Homo sapiens |