Title : High on treatment platelet reactivity against aspirin by non-steroidal anti-inflammatory drugs--pharmacological mechanisms and clinical relevance.

Pub. Date : 2013 May

PMID : 23238666






1 Functional Relationships(s)
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1 This likely occurs within the hydrophobic substrate channel of platelet COX-1 and might be explained by molecular competition between inhibitor drugs and substrate (arachidonic acid) at overlapping binding sites. Arachidonic Acid mitochondrially encoded cytochrome c oxidase I Homo sapiens