Title : Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 in tumors.

Pub. Date : 2013 Jan

PMID : 23232569






1 Functional Relationships(s)
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1 Apart from epigenetic alterations, perturbations in the tricarboxylic acid cycle (depletion of intermediates) and activation of the intricately linked hypoxia signaling pathway are apparent in IDH mutated cells. Tricarboxylic Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens