Pub. Date : 2012 Sep
PMID : 23227542
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The inhibitory effect of icariin on the activity of AChE was investigated by inhibition kinetics. | icariin | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | The results showed that icariin could potently inhibit the activity of AChE, the IC50 value was determined to be 3.50 x 10(-8) mol x L(-1), and the determined IC50 value to tacrine was 0.75 x 10(-8) mol x L(-1). | icariin | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | Kinetic analyses showed that icariin is a reversible and mixed type AChE inhibitor. | icariin | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | Icariin binds selectively to the AChE peripheral anionic site via hydrogen bonds and Van der Waals forces. | icariin | acetylcholinesterase (Cartwright blood group) | Homo sapiens |