Title : Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury.

Pub. Date : 2012

PMID : 23226314






2 Functional Relationships(s)
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1 INTRODUCTION: Uric acid released from injured tissue is considered a major endogenous danger signal and local instillation of uric acid crystals induces acute lung inflammation via activation of the NLRP3 inflammasome. Uric Acid NLR family pyrin domain containing 3 Homo sapiens
2 INTRODUCTION: Uric acid released from injured tissue is considered a major endogenous danger signal and local instillation of uric acid crystals induces acute lung inflammation via activation of the NLRP3 inflammasome. Uric Acid NLR family pyrin domain containing 3 Homo sapiens