Title : Bortezomib is cytotoxic to the human growth plate and permanently impairs bone growth in young mice.

Pub. Date : 2012

PMID : 23226303






1 Functional Relationships(s)
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1 Mechanistic studies of apoptotic pathways indicated that bortezomib induced activation of p53 and Bax, as well as cleavage of caspases and poly-ADP-ribose polymerase (PARP) in exposed chondrocytes. Bortezomib tumor protein p53 Homo sapiens