Pub. Date : 2012
PMID : 23226062
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ABCB1 haplotype and OPRM1 118A > G genotype interaction in methadone maintenance treatment pharmacogenetics. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | BACKGROUND: Genetic variability in ABCB1, encoding the P-glycoprotein efflux transporter, has been linked to altered methadone maintenance treatment dose requirements. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | However, subsequent studies have indicated that additional environmental or genetic factors may confound ABCB1 pharmacogenetics in different methadone maintenance treatment settings. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Therefore, two interacting pharmacogenetic determinants of methadone maintenance treatment response were identified, ie, ABCB1, where variants are associated with lower methadone requirements, and OPRM1, where the variant is associated with higher methadone requirements. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Therefore, two interacting pharmacogenetic determinants of methadone maintenance treatment response were identified, ie, ABCB1, where variants are associated with lower methadone requirements, and OPRM1, where the variant is associated with higher methadone requirements. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | Therefore, two interacting pharmacogenetic determinants of methadone maintenance treatment response were identified, ie, ABCB1, where variants are associated with lower methadone requirements, and OPRM1, where the variant is associated with higher methadone requirements. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |