Title : Cathepsin B and uPAR regulate self-renewal of glioma-initiating cells through GLI-regulated Sox2 and Bmi1 expression.

Pub. Date : 2013 Mar

PMID : 23222817






2 Functional Relationships(s)
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1 Addition of cyclopamine reduced the expression of Sox2 and Bmi1 along with GLI1 and GLI2 expression, induced differentiation and reduced subsphere formation of GICs thereby indicating that hedgehog signaling acts upstream of Sox2 and Bmi1. cyclopamine BMI1 proto-oncogene, polycomb ring finger Homo sapiens
2 Addition of cyclopamine reduced the expression of Sox2 and Bmi1 along with GLI1 and GLI2 expression, induced differentiation and reduced subsphere formation of GICs thereby indicating that hedgehog signaling acts upstream of Sox2 and Bmi1. cyclopamine BMI1 proto-oncogene, polycomb ring finger Homo sapiens