Title : Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion.

Pub. Date : 2013 Jan

PMID : 23221343






1 Functional Relationships(s)
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1 These data demonstrated that CaOx crystals trigger IL-1beta-dependent innate immunity via the NLRP3/ASC/caspase-1 axis in intrarenal mononuclear phagocytes and directly damage tubular cells, leading to the release of the NLRP3 agonist ATP. Adenosine Triphosphate interleukin 1 beta Mus musculus