Title : Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein.

Pub. Date : 2013 Mar

PMID : 23220583






1 Functional Relationships(s)
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1 MTP ASO treatment consistently led to increases in hepatic triglyceride accumulation and biomarkers of hepatotoxicity relative to apoB ASO due in part to enhanced expression of peroxisome proliferator activated receptor gamma target genes and the inability to reduce hepatic fatty acid synthesis. hepatic fatty acid microsomal triglyceride transfer protein Mus musculus