Title : Cardiac glycoside ouabain induces activation of ATF-1 and StAR expression by interacting with the α4 isoform of the sodium pump in Sertoli cells.

Pub. Date : 2013 Mar

PMID : 23220124






1 Functional Relationships(s)
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1 Our recent findings demonstrated that interactions of the alpha4 isoform with cardiotonic steroids (CTS) like ouabain induce signaling cascades that resemble the so-called non-classical testosterone pathway characterized by activation of the c-Src/c-Raf/Erk1/2/CREB signaling cascade. Testosterone mitogen-activated protein kinase 3 Homo sapiens