Pub. Date : 2013 Apr
PMID : 23211530
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, addition of 20muM monensin 1h before CGRP treatment significantly blocked the action of CGRP on surface MORs. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 2 | In living animals, microinjection of CGRP (1nmol in 1mul) into the NAc partially restored morphine antinociception in morphine-tolerant rats, and the effect of CGRP on surface MORs extended beyond normal NAc neurons to chronic morphine-treated NAc neurons. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 3 | In living animals, microinjection of CGRP (1nmol in 1mul) into the NAc partially restored morphine antinociception in morphine-tolerant rats, and the effect of CGRP on surface MORs extended beyond normal NAc neurons to chronic morphine-treated NAc neurons. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 4 | In living animals, microinjection of CGRP (1nmol in 1mul) into the NAc partially restored morphine antinociception in morphine-tolerant rats, and the effect of CGRP on surface MORs extended beyond normal NAc neurons to chronic morphine-treated NAc neurons. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 5 | To conclude, these results demonstrate that CGRP can act on MORs and increase the number of surface MORs in NAc neurons, partially explaining the involvement of opioid receptors in CGRP-induced antinociception in the rat NAc. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |